abstract：OBJECTIVE:Monozygotic twins are usually discordant (only one twin affected) for type 1 diabetes. Discordance for disease between such twins implies a role for nongenetically determined factors but could also be influenced by a decreased load of diabetes susceptibility genes. The aim of this study was to determine wheth...

journal_title：Diabetes care

authors： Metcalfe KA,Hitman GA,Rowe RE,Hawa M,Huang X,Stewart T,Leslie RD

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:Advanced glycation end products (AGEs) are a risk factor for diabetic complications. We have developed an assay method for N-(carboxymethyl)valine (CMV) of the hemoglobin (CMV-Hb), which is an AGE generated from HbA1c. Herein we describe the clinical utility of CMV-Hb measurement for the diagnosis of diabetic...

journal_title：Diabetes care

authors： Uchimura T,Nakano K,Hashiguchi T,Iwamoto H,Miura K,Yoshimura Y,Hanyu N,Hirata K,Imakuma M,Motomiya Y,Maruyama I

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:To evaluate and validate appropriate premeal insulin dose reductions for postprandial exercises of different intensities and durations to minimize the risk of exercise-induced hypoglycemia in type 1 diabetic subjects. RESEARCH DESIGN AND METHODS:Eight male type 1 diabetic patients on a basal-bolus insulin re...

journal_title：Diabetes care

authors： Rabasa-Lhoret R,Bourque J,Ducros F,Chiasson JL

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To examine the relationship between disordered eating attitudes and behaviors, BMI, and glycemic control in adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:In a cross-sectional design, 152 adolescents (ages 11-19 years) completed three scales from the Eating Disorders Inventory (EDI): Body Diss...

journal_title：Diabetes care

authors： Meltzer LJ,Johnson SB,Prine JM,Banks RA,Desrosiers PM,Silverstein JH

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:Sulfonylureas block the activation of vascular potassium-dependent ATP channels and impair the vasodilating response to ischcmia in nondiabetic individuals, but it is not know whether this occurs in type 2 diabetic patients under chronic treatment with these drugs. Glimepiride, a new sulfonylurea, apparently ...

journal_title：Diabetes care

authors： Spallarossa P,Schiavo M,Rossettin P,Cordone S,Olivotti L,Cordera R,Brunelli C

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:We have demonstrated high heritability of insulin secretion measured as acute insulin response to glucose times insulin sensitivity (disposition index). Furthermore, we showed that obese normoglycemic family members of a type 2 diabetic proband failed to compensate for the insulin resistance of obesity by inc...

journal_title：Diabetes care

authors： Elbein SC,Sun J,Scroggin E,Teng K,Hasstedt SJ

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:To determine whether there is a familial abnormality in erythrocyte Na/Li countertransport (CT) kinetics in the approximate one-third of type 1 diabetic patients that succumb to a familial predisposition to nephropathy. RESEARCH DESIGN AND METHODS:Erythrocyte Na/Li CT kinetics were measured in nondiabetic fi...

journal_title：Diabetes care

authors： Mead PA,Wilkinson R,Thomas TH

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:Consumption of soy protein has recently been shown to improve the blood lipid levels in nondiabetic subjects. The purpose of this study was to evaluate if a dietary supplement of soy protein, isoflavones, and cotyledon fiber (Abalon) affects cardiovascular risk markers, blood glucose, and insulin levels in ty...

journal_title：Diabetes care

authors： Hermansen K,Søndergaard M,Høie L,Carstensen M,Brock B

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To determine the incidence of retinopathy and the relative importance of its risk factors in type 1 diabetes. RESEARCH DESIGN AND METHODS:This is a 7.3-year follow-up of 764 of 1,215 (63%) people with type 1 diabetes across Europe, aged 15-60 years at baseline with no retinopathy (the EURODIAB Prospective Co...

journal_title：Diabetes care

authors： Chaturvedi N,Sjoelie AK,Porta M,Aldington SJ,Fuller JH,Songini M,Kohner EM,EURODIAB Prospective Complications Study.

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To examine the contribution of nerve-axon reflex-related vasodilation to total acetylcholine-induced vasodilation in the skin of normal and diabetic subjects. RESEARCH DESIGN AND METHODS:The skin microcirculation was evaluated at the forearm level in 69 healthy subjects and 42 nonneuropathic diabetic patient...

journal_title：Diabetes care

authors： Hamdy O,Abou-Elenin K,LoGerfo FW,Horton ES,Veves A

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:Because a pseudonormal pattern of ventricular filling has never been considered in studies that reported a prevalence of left ventricular diastolic dysfunction (LVDD) between 20 and 40%, our aim was to more completely evaluate the prevalence of LVDD in subjects with diabetes. RESEARCH DESIGN AND METHODS:We s...

journal_title：Diabetes care

authors： Poirier P,Bogaty P,Garneau C,Marois L,Dumesnil JG

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:We have previously suggested using the paired values of fasting plasma glucose (FPG) and HbA1c to identify potential diabetic subjects. In this article, we followed up on 208 nondiabetic subjects and examined their rates of progression to diabetes. We analyzed their likelihood of becoming diabetic according t...

journal_title：Diabetes care

authors： Ko GT,Chan JC,Tsang LW,Cockram CS

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVE:To assess if low (1.25 mg) and/or standard (5 mg) doses of the ACE inhibitor ramipril could prevent progression of microalbuminuria (incipient diabetic nephropathy) in normotensive type 1 diabetic patients. RESEARCH DESIGN AND METHODS:This study, using a multicenter randomized placebo-controlled double-blind...

journal_title：Diabetes care

authors： O'Hare P,Bilbous R,Mitchell T,O' Callaghan CJ,Viberti GC,Ace-Inhibitor Trial to Lower Albuminuria in Normotensive Insulin-Dependent Subjects Study Group.

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVE:To determine the safety and efficacy of the long-acting insulin analog, insulin glargine, as a component of basal bolus therapy in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Patients with type 1 diabetes receiving basal-bolus insulin treatment with NPH human insulin and insulin lispro were ra...

journal_title：Diabetes care

authors： Raskin P,Klaff L,Bergenstal R,Hallé JP,Donley D,Mecca T

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:Microalbuminuria can reflect the progress of microvascular complications and may be predictive of macrovascular disease in type 2 diabetes. The effect of intensive glycemic control on microalbuminuria in patients in the U.S. who have had type 2 diabetes for several years has not previously been evaluated. RE...

journal_title：Diabetes care

authors： Levin SR,Coburn JW,Abraira C,Henderson WG,Colwell JA,Emanuele NV,Nuttall FQ,Sawin CT,Comstock JP,Silbert CK

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:Congenital generalized lipodystrophy (CGL) is an autosomal recessive genetic disorder characterized by almost complete absence of adipose tissue, muscular appearance, and severe insulin resistance since birth. We investigated whether insulin resistance in CGL patients is associated with abnormal muscle morpho...

journal_title：Diabetes care

authors： Garg A,Stray-Gundersen J,Parsons D,Bertocci LA

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:Of patients who are prescribed metformin, 10-30% have evidence of reduced vitamin B12 absorption. B12-intrinsic factor complex uptake by ileal cell surface receptors is known to be a process dependent on calcium availability Metformin affects calcium-dependent membrane action. The objective of this study was ...

journal_title：Diabetes care

authors： Bauman WA,Shaw S,Jayatilleke E,Spungen AM,Herbert V

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:To examine the significance of individual risk factors on the development of diabetes in subjects who underwent screening for diabetes. RESEARCH DESIGN AND METHODS:A total of 1,649 Chinese subjects underwent screening for diabetes. They were asymptomatic but had known risk factors for diabetes, including a p...

journal_title：Diabetes care

authors： Ko GT,Chan JC,Tsang LW,Yeung VT,Chow CC,Cockram CS

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:To study the metabolic effect and the variability of the effect elicited by inhalation of 87.2 U insulin powder combined with an absorption enhancer. The metabolic effect was compared with that of 10.2 U regular insulin injected subcutaneously and of 5.5 U regular insulin given intravenously RESEARCH DESIGN ...

journal_title：Diabetes care

authors： Heinemann L,Klappoth W,Rave K,Hompesch B,Linkeschowa R,Heise T

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:Endothelial markers endothelin 1 (ET-1) and von Willebrand factor (vWF) were assessed in patients with type 2 diabetes and dyslipidemia and in patients with hypercholesterolemia. RESEARCH DESIGN AND METHODS:In this case-control study, plasma ET-and vWF levels were measured by enzyme-linked immunosorbent assa...

journal_title：Diabetes care

authors： Seligman BG,Biolo A,Polanczyk CA,Gross JL,Clausell N

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:To examine trends in diabetes prevalence in the U.S. RESEARCH DESIGN AND METHODS:This study was conducted via telephone surveys in states that participated in the Behavioral Risk Factor Surveillance System between 1990 and 1998. The participants consisted of noninstitutionalized adults aged 18 years or older...

journal_title：Diabetes care

authors： Mokdad AH,Ford ES,Bowman BA,Nelson DE,Engelgau MM,Vinicor F,Marks JS

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:To investigate whether the presence of antibody markers at diagnosis could help predict the rapid decrease in residual beta-cell function noted in some, but not all, patients with recent-onset type 1 diabetes. RESEARCH DESIGN AND METHODS:We measured random C-peptide levels (radioimmunoassay); islet cell cyto...

journal_title：Diabetes care

authors： Decochez K,Keymeulen B,Somers G,Dorchy H,De Leeuw IH,Mathieu C,Rottiers R,Winnock F,ver Elst K,Weets I,Kaufman L,Pipeleers DG,Gorus FK,Belgian Diabetes Registry.

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:Available basal insulin formulations do not provide a constant and reliable 24-h insulin supply. We compared the efficacy and safety of glargine (a long-acting insulin analog) and NPH insulins in insulin-naive type 2 diabetic patients treated with oral antidiabetic agents. RESEARCH DESIGN AND METHODS:There w...

journal_title：Diabetes care

authors： Yki-Järvinen H,Dressler A,Ziemen M,HOE 901\/300s Study Group.

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to compare clinical and biomechanical characteristics of balance in diabetic polyneuropathic elderly patients and normal age-matched subjects. RESEARCH DESIGN AND METHODS:Fifteen elderly with distal neuropathy (DNP) and 15 healthy age-matched subjects were evaluated with the b...

journal_title：Diabetes care

authors： Corriveau H,Prince F,Hébert R,Raîche M,Tessier D,Maheux P,Ardilouze JL

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:Some evidence suggests an inverse association between type 2 diabetes and androgens in men and a positive association between type 2 diabetes and androgens in women. The purpose of this community-based study was to evaluate sex differences in the association between endogenous total and bioavailable estrogen ...

journal_title：Diabetes care

authors： Goodman-Gruen D,Barrett-Connor E

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:This multicenter open-label clinical trial compared the efficacy and safety of repaglinide/troglitazone combination therapy, repaglinide monotherapy, and troglitazone monotherapy in type 2 diabetes that had been inadequately controlled by sulfonylureas, acarbose, or metformin alone. RESEARCH DESIGN AND METHO...

journal_title：Diabetes care

authors： Raskin P,Jovanovic L,Berger S,Schwartz S,Woo V,Ratner R

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:Existing physical examination scoring systems for distal diabetic polyneuropathy (PNP) do not fulfill all of the following criteria: validity, manageability, predictive value, and hierarchy The aim of this study was to adapt the Neuropathy Disability Score (NDS) to diagnose PNP in diabetes so that it fulfills...

journal_title：Diabetes care

authors： Meijer JW,van Sonderen E,Blaauwwiekel EE,Smit AJ,Groothoff JW,Eisma WH,Links TP

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:Studies in animal models suggest that ovarian hormone deficiency is associated with the development of insulin resistance. In women, ovarian hormone levels are dramatically reduced after the menopause transition. However, the effect of the menopause transition on insulin sensitivity is unclear. Thus, we exami...

journal_title：Diabetes care

authors： Toth MJ,Sites CK,Eltabbakh GH,Poehlman ET

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:Elevated heart rate has been predictive of cardiovascular disease and has been proposed as a global index of the autonomic nervous system influence on the heart. Hyperinsulinism has been shown to trigger sympathetic activity experimentally; however, the clinical and epidemiological data on the association of ...

journal_title：Diabetes care

authors： Festa A,D'Agostino R Jr,Hales CN,Mykkänen L,Haffner SM

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:The objective was to examine prospectively the association between low testosterone and sex hormone-binding globulin (SHBG) levels and the subsequent development of type 2 diabetes in men. RESEARCH DESIGN AND METHODS:Analyses were conducted on the cohort of the Massachusetts Male Aging Study, a population-ba...

journal_title：Diabetes care

authors： Stellato RK,Feldman HA,Hamdy O,Horton ES,McKinlay JB

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of the insertion/deletion polymorphism of the ACE gene on the progression of early diabetic glomerulopathy in patients with and without antihypertensive treatment (AHT). RESEARCH DESIGN AND METHODS:There were 30 microalbuminuric patients with >5 years of type 1 diabetes who had r...

journal_title：Diabetes care

authors： Rudberg S,Rasmussen LM,Bangstad HJ,Osterby R

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:Whether ACE inhibition is useful for type 2 diabetic patients with micro- and macroalbuminuria remains unknown. The Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria, Cardiovascular Events and Ramipril (DIABHYCAR) Study was set up to address this issue through a multicenter double-blind parallel ...

journal_title：Diabetes care

authors： Marre M,Lièvre M,Vasmant D,Gallois Y,Hadjadj S,Reglier JC,Chatellier G,Mann J,Viberti GC,Passa P

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:To determine the characteristics that influence glycemic control among insulin-using adults with type 2 diabetes. RESEARCH DESIGN AND METHODS:We studied all 1,333 eligible members of a large not-for-profit health maintenance organization who responded to a 1997 survey. We tested associations among demographi...

journal_title：Diabetes care

authors： Nichols GA,Hillier TA,Javor K,Brown JB

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:To determine if differing beliefs about high blood glucose exist and are associated with blood glucose control among rural African-Americans. RESEARCH DESIGN AND METHODS:A community-based sample of rural African-Americans completed a survey, and a subsample underwent a subsequent screening that included gluc...

journal_title：Diabetes care

authors： Schorling JB,Saunders JT

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:We evaluated a program of performance measurement and monitoring by assessing care process, utilization of services, and outcomes. RESEARCH DESIGN AND METHODS:Information on 63,264 diabetic individuals who were continuously enrolled as members of Kaiser Permanente Southern California from 1 January 1994 to 3...

journal_title：Diabetes care

authors： Petitti DB,Contreras R,Ziel FH,Dudl J,Domurat ES,Hyatt JA

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:Dietary fiber has recently received recognition for reducing the risk of developing diabetes and heart disease. The implication is that it may have therapeutic benefit in prediabetic metabolic conditions. To test this hypothesis, we investigated the effect of supplementing a high-carbohydrate diet with fiber ...

journal_title：Diabetes care

authors： Vuksan V,Sievenpiper JL,Owen R,Swilley JA,Spadafora P,Jenkins DJ,Vidgen E,Brighenti F,Josse RG,Leiter LA,Xu Z,Novokmet R

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To characterize metabolic effects of troglitazone in type 2 diabetic, obese, and lean subjects, and examine the effects of troglitazone 2-3 weeks after discontinuation. RESEARCH DESIGN AND METHODS:Nine type 2 diabetic, nine obese, and nine lean subjects underwent baseline metabolic studies including an 8-h m...

journal_title：Diabetes care

authors： Frias JP,Yu JG,Kruszynska YT,Olefsky JM

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the short-term impact of a 7-h type 2 diabetes continuing medical education (CME) program. Outcomes included a measure of health care providers' diabetes knowledge and the Diabetes Attitude Scale (DAS), a validated measure of attitudes toward diabetes. RESEARCH DES...

journal_title：Diabetes care

authors： Sharp LK,Lipsky MS

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:To investigate whether the use of exogenous estrogen is associated with changes in the severity of diabetic retinopathy and the incidence of macular edema. RESEARCH DESIGN AND METHODS:The study design involved observation of two well-defined cohorts of women with diabetes. One group was diagnosed with diabet...

journal_title：Diabetes care

authors： Klein BE,Klein R,Moss SE

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:To investigate whether the fall in soluble L-selectin (sL-selectin) level constitutes a marker for myocardial ischemia. RESEARCH DESIGN AND METHODS:The levels of soluble forms of adhesion molecules, i.e., intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), E-selectin (sE...

journal_title：Diabetes care

authors： Albertini JP,Valensi P,Lormeau B,Vaysse J,Attali JR,Gattegno L

更新日期：1999-12-01 00:00:00